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TheBrief.Health

Living with mismatch repair deficiency

Stories from people navigating mismatch repair deficiency — diagnosis, treatment, caregiving, and the ordinary days in between.

6 stories

Pelvic MRI beside a multidisciplinary rectal cancer treatment plan and pathology report.

Oncology

Dostarlimab Reframes Organ Preservation in Rectal Cancer

Accelerated approval adds dostarlimab as an initial option for selected patients with untreated stage II or III MSI-H or dMMR rectal cancer, making organ preservation an early multidisciplinary decision.

Rayan Salih · 6 min read

Rectal cancer pathology slides beside a molecular testing report and multidisciplinary treatment notes.

Oncology

Rectal Cancer: Who Fits the Dostarlimab Approval

The FDA approval applies to adults with untreated stage II or III locally advanced rectal cancer whose tumors are MSI-H or dMMR. Testing must occur before the initial treatment strategy is fixed.

Rayan Salih · 6 min read

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