Across the specialties
Concise evidence briefs from across internal medicine, surgery, pediatrics and primary care.
Clinical Briefs
Traditional approval retains a narrow, tissue-agnostic indication for adults and children with previously treated, unresectable or metastatic TMB-high solid tumors and no satisfactory alternatives.
Rayan Salih · October 28, 2026 · 6 min
Clinical Briefs
A Class I recall covers convenience kits containing potentially nonsterile 0.9% sodium chloride flush ampules. Affected ampules should be removed and discarded to prevent intravenous exposure.
Rayan Salih · 6 min read
Clinical Briefs
The supplied FDA index does not provide enough decision-specific information to verify a new tucatinib, trastuzumab and pertuzumab maintenance indication.
Rayan Salih · 6 min read
Clinical Briefs
A nationwide recall covers compounded glutathione, Myers’ cocktail and Tri-Immune Boost injections. Infusion practices should quarantine affected stock and review patient exposure.
Dr. Abu Bakar · 7 min read
Clinical Briefs
Temporary FDA guidance creates a regulatory bridge for neonatal starter parenteral nutrition as the predominant market source prepares to exit. Hospital pharmacies still must meet the policy’s conditions and core quality obligations.
Dr. Abu Bakar · 7 min read
Clinical Briefs
The FDA expanded a Class I recall covering specific lots of reprocessed electrophysiology and ultrasound catheters because particulates may remain on patient-contacting surfaces.
Dr. Abu Bakar · 6 min read
Clinical Briefs
One recalled lot labeled as 0.9% sodium chloride injection may expose patients to concentrated potassium chloride. Hospitals, pharmacies and infusion services should rapidly isolate affected inventory and trace possible use.
Rayan Salih · 6 min read
Clinical Briefs
Par Health recalled two lots of dexmedetomidine injection over particulate matter. Hospitals should trace inventory, replace affected infusions and assess exposed patients.
Rayan Salih · 7 min read
Clinical Briefs
Randomized comparative evidence favors fecal microbiota transplantation over vancomycin or fidaxomicin for selected adults with recurrent C. difficile infection, particularly after multiple recurrences.
Rayan Salih · 6 min read
Clinical Briefs
The 2026 universal definition gives emergency, outpatient and inpatient teams a shared framework for identifying heart failure, but local rules must still address coding, referrals and program eligibility.
Rayan Salih · 7 min read
Clinical Briefs
A nationwide recall of 0.9% sodium chloride injection requires US hospitals, pharmacies and infusion services to quarantine affected lots and coordinate safe replacement supply.
Dr. Abu Bakar · 6 min read
Clinical Briefs
A nationwide cohort associated SGLT2 inhibitors with lower heart-failure hospitalization and all-cause mortality risks than DPP-4 inhibitors or sulfonylureas in HFpEF and type 2 diabetes.
Dr. Abu Bakar · 6 min read
Clinical Briefs
The FDA reported 184 serious injuries and no deaths involving specified Medtronic and Given Imaging esophageal pH capsule delivery devices. Gastroenterology services should review inventory, workflows and follow-up.
Rayan Salih · 7 min read
Clinical Briefs
FDA approval of RefluxStop requires a prospective study of 200 patients with GERD, reflecting unresolved questions about long-term implant safety, effectiveness and durability.
Dr. Abu Bakar · 6 min read
Clinical Briefs
An FDA-posted recall covers an affected lot of tocilizumab-aazg (Tyenne) vials because of possible glass particles. Clinicians should separate patient assessment from inventory control.
Rayan Salih · 6 min read
Clinical Briefs
WHO recommends hydroxyurea for all children and adolescents with sickle cell anemia from 9 months to 19 years, shifting care toward early treatment regardless of symptom history.
Rayan Salih · 7 min read
Clinical Briefs
Fresenius Kabi recalled one lot of morphine sulfate injection after a label mix-up could expose patients to hydromorphone, creating a risk of opioid overdose and respiratory depression.
Rayan Salih · 6 min read
Clinical Briefs
In FLOW, semaglutide reduced major kidney outcomes and cardiovascular death among adults with type 2 diabetes and albuminuric chronic kidney disease.
Rayan Salih · 6 min read
Clinical Briefs
Disorders of gut-brain interaction (DGBI)—formerly classified as functional gastrointestinal disorders—affect over 40% of the population globally.
Rayan Salih · 8 min read
Clinical Briefs
Sirolimus conversion is an increasingly considered strategy for heart transplant recipients because it can change their long-term health risks….
Dr. Abu Bakar · 6 min read
Clinical Briefs
The clinical landscape of autism spectrum disorder (ASD) is undergoing a profound dual transformation.
Rayan Salih · 9 min read
Clinical Briefs
The therapeutic management of migraines has undergone a seismic shift over the past decade.
Rayan Salih · 8 min read
Clinical Briefs
Endovascular band placement is a minimally invasive way to control lung blood flow in infants born with certain
Dr. Abu Bakar · 7 min read
Clinical Briefs
A baby’s safest sleep can depend on just a few simple choices, yet for many new parents, those
Dr. Abu Bakar · 7 min read
Clinical Briefs
Small changes can make a big difference to health and wellbeing.
Dr. Abu Bakar · 14 min read
Clinical Briefs
The issue of erectile dysfunction (ED) in the younger male is becoming increasingly obvious in the clinic and
Dr. Abu Bakar · 13 min read
Clinical Briefs
Screening for prostate cancer has become routine, but guidelines for screening are evolving.
Dr. Abu Bakar · 12 min read
Clinical Briefs
Collagen supplements have moved from niche wellness aisles into mainstream use by people seeking clearer skin, stronger bones,
Dr. Abu Bakar · 10 min read
Clinical Briefs
Due to a variety of reasons men do not seek or receive timely and appropriate health care.
Dr. Abu Bakar · 13 min read
Clinical Briefs
While many clinicians are unaware that a predictive model is involved in much of the AI that is
Dr. Abu Bakar · 18 min read
Clinical Briefs
Individuals who are both vision impaired and hearing impaired typically gain less from standard vision rehabilitation than individuals
Dr. Abu Bakar · 13 min read
Clinical Briefs
Our growing understanding of the role of immune signalling in AML that fails treatment is rapidly challenging our
Dr. Abu Bakar · 12 min read
Clinical Briefs
What every clinician needs to know about IgA nephropathy and IgA vasculitis in 2025?
Dr. Abu Bakar · 12 min read
Clinical Briefs
A gut bug known as Ruminococcus gnavus, or gut bug Ruminococcus gnavus, or simply gut bug R.
Dr. Abu Bakar · 14 min read
Clinical Briefs
Several Medicare Administrative Contractors (MACs) have issued draft Medicare coverage policies regarding peripheral nerve blocks and denervation procedures
Dr. Abu Bakar · 9 min read
Clinical Briefs
Preliminary pilot data from pilot rural and urban practices in three states suggest that the combination of pharmacologic
Dr. Abu Bakar · 12 min read
Clinical Briefs
Ferroptosis is a novel form of iron-dependent regulated cell death, characterized by the production of toxic lipid peroxides….
Dr. Abu Bakar · 11 min read
Clinical Briefs
Studies suggest that individuals with IBS may be at increased risk of being subsequently diagnosed with IBD.
Dr. Abu Bakar · 14 min read
Clinical Briefs
Healthy aging has become a daily clinical problem as more and more older patients live longer with more
Dr. Abu Bakar · 15 min read
Clinical Briefs
Alopecia areata presents clinicians and their patients with significant challenges in balancing risk and benefit, particularly as it
Dr. Abu Bakar · 13 min read
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