The archive

All stories

391 stories, newest first — page 3 of 17.

Latest briefs

Laboratory stool-testing materials beside a public health case investigation form and packaged fresh produce.

Health Policy

Cyclosporiasis Surveillance Shows Substantial 2026 Burden

CDC counted 17,180 laboratory-confirmed US cyclosporiasis cases since May 1, 2026, while at least 11,844 additional cases remained under investigation.

Rayan Salih · 6 min read

Coronary stent model beside aspirin and antiplatelet tablets on a clinical work surface.

Cardiology

Shorter DAPT After PCI May Cut Bleeding Without More MACE

A randomized-trial meta-analysis found less major bleeding with 3–6 months of DAPT after PCI than with 12 months, while major cardiovascular events were not significantly increased.

Rayan Salih · 6 min read

Pancreatic anatomy diagram beside a pathology slide and medication container on a clinical workstation.

Oncology

Daraxonrasib Adds a Metastatic Pancreatic Cancer Option

The FDA approved daraxonrasib for adults with metastatic pancreatic adenocarcinoma after systemic therapy or when multi-agent therapy is not feasible.

Rayan Salih · 6 min read

Unbranded pediatric medicine packaging and an oral dosing syringe arranged on a pharmacy work surface.

Health Policy

WHO Targets Pediatric Hydroxyurea for Sickle Cell Disease

WHO’s pediatric target product profile could align hydroxyurea development and procurement for children and adolescents with sickle cell disease, but formulation alone will not secure equitable access.

Rayan Salih · 7 min read

Breast cancer pathology slide beside a molecular test report indicating PIK3CA wild-type status.

Oncology

Gedatolisib Approved for PIK3CA-Wild-Type Breast Cancer

The FDA approved gedatolisib plus fulvestrant, with or without palbociclib, after endocrine therapy progression in PIK3CA-wild-type HR-positive, HER2-negative advanced breast cancer.

Rayan Salih · 6 min read

Oncology

Ivonescimab Improves Survival in Squamous NSCLC Trial

In China’s phase 3 HARMONi-6 trial, ivonescimab plus chemotherapy improved interim overall survival versus tislelizumab plus chemotherapy in advanced squamous NSCLC.

Rayan Salih · 6 min read

Breast cancer pathology slides beside medication packaging and a clinician’s treatment-planning notes.

Oncology

Adjuvant CDK4/6 Benefits Diverge in Early Breast Cancer

A meta-analysis found invasive disease-free survival gains with adjuvant abemaciclib and ribociclib, but not palbociclib, in HR-positive, HER2-negative early breast cancer.

Rayan Salih · 7 min read

Hydroxyurea bottle beside pediatric laboratory supplies and a sickle cell care pathway document

Clinical Briefs

Sickle Cell Anemia Guidance Expands Hydroxyurea Access

WHO recommends hydroxyurea for all children and adolescents with sickle cell anemia from 9 months to 19 years, shifting care toward early treatment regardless of symptom history.

Rayan Salih · 7 min read

Blood pressure cuff beside adrenal imaging and laboratory request forms on a clinician’s desk.

Endocrinology & Metabolism

Primary Aldosteronism Evidence Reshapes Care Pathways

The supporting systematic review favors aldosterone-directed treatment and clearer selection between adrenalectomy and medical therapy for adults with primary aldosteronism.

Rayan Salih · 7 min read

Packaged vascular devices being checked against a recall notice in a hospital supply area

Innovation & Devices

ENROUTE Class I Recall Requires Immediate Lot Review

Specified ENROUTE neuroprotection system lots were recalled after arterial sheath tip separation reports. Transcarotid teams should quarantine inventory and review potentially affected procedures.

Rayan Salih · 6 min read

Myeloma treatment vials and clinical documents arranged on a hospital pharmacy work surface.

Oncology

Iberdomide Combination Approved for Relapsed Myeloma

The accelerated approval covers eligible adults with previously treated multiple myeloma after exposure to both a proteasome inhibitor and an immunomodulatory agent.

Rayan Salih · 6 min read

COVID-19 vaccine vials beside a calendar and a clinical risk-prioritization checklist.

Infectious Disease

WHO Updates COVID-19 Vaccine Priorities and Schedules

WHO’s 2026 position paper simplifies primary vaccination and concentrates repeat doses on people at greatest risk of severe COVID-19. US clinicians must still follow CDC schedules and FDA-authorized formulations.

Rayan Salih · 6 min read

Pathology slides and HER2 testing materials beside an upper gastrointestinal cancer treatment plan.

Oncology

Zanidatamab Expands First-Line HER2-Positive GI Care

The FDA authorized two zanidatamab-based first-line strategies for unresectable locally advanced or metastatic HER2-positive gastric, gastroesophageal junction, and esophageal adenocarcinoma.

Rayan Salih · 6 min read

Cardiac MRI equipment prepared for monitoring heart function in Duchenne muscular dystrophy care.

Innovation & Devices

Deramiocel for Duchenne Muscular Dystrophy: FDA Review Raises Questions About Cardiac Benefit

FDA advisers examined whether deramiocel’s cardiac and upper-limb findings outweigh uncertainties in the evidence and risks of repeated cell infusions for Duchenne muscular dystrophy.

Dr. Abu Bakar · 7 min read

Illustration of an intratumoral viral therapy vial beside a melanoma pathology slide and checkpoint immunotherapy infusion bag.

Oncology

FDA Grants Accelerated Approval to Tudriqev Plus Nivolumab for Advanced Melanoma After PD-1 Progression

The FDA granted accelerated approval to vusolimogene oderparepvec plus nivolumab for unresectable advanced melanoma progressing after PD-1 therapy, based on tumor response and response durability.

Dr. Abu Bakar · 6 min read

A border health desk with protective supplies, reporting forms, radios, and a regional map prepared for Ebola surveillance.

Infectious Disease

Bundibugyo Ebola Outbreak in DRC: What Clinicians and Public Health Teams Need to Know

Rapid case growth and very-high national risk in DRC warrant stronger clinical preparedness and cross-border surveillance, while WHO assesses global risk as low and advises against travel or trade restrictions.

Dr. Abu Bakar · 7 min read

Clinician workspace with a heart model, kidney model, glucose meter and integrated prevention checklist.

Cardiology

2026 CKM Guideline: Earlier, Integrated Prevention for Heart, Kidney and Metabolic Health

The 2026 CKM guideline calls for earlier, integrated prevention when cardiovascular, kidney and metabolic risks coexist, with action spanning primary care, endocrinology, nephrology and cardiology.

Dr. Abu Bakar · 7 min read

Packaged alfalfa sprouts set aside in a refrigerator during a foodborne outbreak investigation.

Infectious Disease

E. Coli and Salmonella Outbreak Linked to Alfalfa Sprouts

A multistate outbreak linked to affected alfalfa sprouts requires exposure-specific histories, testing for both pathogens and prompt coordination with public health agencies.

Dr. Abu Bakar · 6 min read

Sealed catheter introducer kits and an Impella supply checklist in a cardiac procedure room

Innovation & Devices

Impella Introducer Recall Requires Kit-Level Checks

The FDA’s Class I classification covers certain catheter introducers in kits used with Impella heart pumps. Heart teams should verify identifiers and incorporate the manufacturer’s correction into procedural checks.

Rayan Salih · 6 min read

Oncology

Myeloma Survival Unchanged With Longer Lenalidomide

In ENDURANCE, indefinite lenalidomide maintenance did not improve 7-year overall survival versus a fixed 2-year course for standard-risk myeloma managed without upfront transplant.

Rayan Salih · 6 min read

Primary care desk with a blood pressure cuff, walking shoes and cognitive assessment materials

Neurology

WHO Dementia Risk Guidance Needs Source Verification

The cited 2026 WHO media-briefing record does not provide enough verifiable detail to identify revised dementia recommendations. Established guidance still supports integrating cardiovascular and behavioral risk reduction into routine care.

Rayan Salih · 6 min read

An OTC orlistat package beside a medication list and kidney-shaped clinical model on a pharmacy counter.

Endocrinology & Metabolism

Orlistat Kidney-Injury Warning Now Covers OTC Alli

The FDA has approved revised labeling for OTC orlistat (alli) warning of rare acute kidney injury, bringing kidney-risk messaging into line across US orlistat products.

Rayan Salih · 6 min read

Pharmacist checking injectable vial lot numbers beside a quarantined medication bin

Infectious Disease

Tocilizumab Recall Demands Rapid Inventory Controls

One lot of intravenous tocilizumab-aazg (Tyenne) was recalled nationwide over possible glass particles. Infusion centers, pharmacies and clinics should rapidly quarantine stock and trace prior distribution.

Rayan Salih · 7 min read

Rivaroxaban tablets beside a kidney model and a clinical medication review sheet.

Cardiology

Advanced CKD: Rivaroxaban Adds Bleeding, Not Benefit

TRACK found no cardiovascular benefit and more major bleeding when low-dose rivaroxaban was added in stage 4–5 CKD or dialysis-dependent kidney failure.

Rayan Salih · 6 min read